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A -- Preparation of Developing Brain Tissue from Rhesus macaque for Gene Expression Analysis

Solicitation Number: NIMH-08-DN-00018
Agency: Department of Health and Human Services
Office: National Institutes of Health
Location: National Institute on Mental Health
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NIMH-08-DN-00018
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Solicitation
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Added: March 7, 2008
The National Institute of Mental Health (NIMH) intends to issue a Request for Proposals (RFP No. NIMH-08-DN-00018) entitled Preparation of Developing Brain Tissue from Rhesus macaque for Gene Expression Analysis, on or about March 25, 2008, under full and open competitive procedures.

As the lead institute for this NIH Blueprint project, NIMH is seeking organizations and investigators with access to appropriate colonies of Rhesus macaque primates, and with expertise in extracting anatomically defined brain regions from non-human primates (Maccaca mulatta) at different developmental stages that range from pre-natal to adult. This project will involve collecting tissue from estimated 4-6 brain regions, from 4-6 animals, at 5 different developmental time points over the course of two years. There will be options to extend the contract beyond 2 years, which would require additional tissue samples. The facility/investigator must have access to animals that come from well-defined colonies with the following characteristics/data available: 1) the lineage and hierarchical status of each animal is characterized in detail; 2) the exact date of birth of the animals is documented; 3) animals are nursery reared; 4) the animals are raised in naturalistic group settings (i.e., free-ranging colonies in large outdoor corrals, housed to allow for normal social interactions); and 5) the animals kept at institutions with a currently approved DHHS Animal Welfare Assurance. IACUC approval will be mandatory for this project prior award of the contract.



In addition to access to appropriate animals, capable sources/investigators must have the following documented experience and capabilities: 1) expertise in Rhesus macaque neuroanatomy; 2) expertise in the dissection and blocking of tissue from specific brain regions in Rhesus macaque primates; 3) expertise in the preparation of tissue for in situ hybridization analysis and Nissl staining (note: these will be performed at a separate facility); and 4) expertise in the shipping/transportation of biohazardous materials to another facility for further processing. This contract will be the sole supplier of brain samples to another contractor for processing, and will be required to work effectively and closely with the other facility.



RFP No. NIMH-08-DN-00018 will be available on or about March 25, 2008 with the receipt date of proposals on or about May 23, 2008. The RFP may be accessed through the following site: Federal Business Opportunities (http://www.fbo.gov/). Please note that the RFP for this requirement will include the Statement of Work, Deliverables, and Reporting Requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offeror will be contained in the electronic RFP package. All responsible sources are encouraged to submit a proposal that will be considered by the NIMH. This advertisement does not commit the Government to award a contract. Please contact Bruce Anderson, NIMH Contracting Officer, at 301-443-2234 or ba9i@nih.gov for further information.

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Solicitation 1

Type:
Solicitation
Posted Date:
March 25, 2008
toc.pdf (221.67 Kb)
Description: Solicitation for Preparation of Developing Brain Tissue from Rhesus Macaque for Gene Expression Analysis

Solicitation 2

Type:
Solicitation
Posted Date:
March 25, 2008
Description: Attachment - 2
Description: Attachment - 3 (SOW)
Description: Attachment - 4
Description: Attachment -1
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Department of Health and Human Services, National Institutes of Health, National Institute on Mental Health, Contracts Management Branch 6001 Executive Blvd, Rm 8154, MSC 9661, Bethesda, MD, 20892-9661, UNITED STATES
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20892
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Bruce Anderson, Contracting Officer, Phone 301-443-2234, Fax 301-443-0501, Email ba9i@nih.gov - Bruce Anderson, Contracting Officer, Phone 301-443-2234, Fax 301-443-0501, Email ba9i@nih.gov