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B Cell Epitope Discovery and Mechanisms of Antibody Protection

Solicitation Number: BAA-NIAID-DAIT-NIHAI2013164
Agency: Department of Health and Human Services
Office: National Institutes of Health
Location: National Institute of Allergy and Infectious Diseases
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There have been modifications to this notice. To view the most recent modification/amendment, click here
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BAA-NIAID-DAIT-NIHAI2013164
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Solicitation
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Added: Mar 01, 2013 10:21 am
Introduction

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), of the Department of Health and Human Services (DHHS) supports research related to the basic understanding of microbiology and immunology leading to the development of vaccines, therapeutics, and medical diagnostics for the prevention, treatment, and diagnosis of infectious and immune-mediated diseases. The NIAID/Division of Allergy, Immunology, and Transplantation has a requirement for research aimed at the discovery of novel B cell epitopes and elucidation of mechanisms of antibody-mediated protection or pathogenesis. This program emphasizes discovery for NIAID Emerging/Re-emerging Infectious Diseases.


Description


This program will support the identification of linear and conformational B cell epitopes, coupled with basic studies to understand protective immunity and/or pathogenesis mediated by pathogen-specific antibodies. Investigators may utilize established technologies for epitope discovery or develop new or improved technologies for the identification of novel B cell epitopes. Epitope discovery methods must be accompanied by basic studies using human samples to validate identified epitopes as targets of B cell/antibody recognition, and to help understand mechanisms by which the antibodies might induce immune protection or pathogenesis. Investigators may, but are not required to include studies in appropriate animal models. Supported investigators will be required to attend an annual program review meeting at NIH and submit their epitope information to the Immune Epitope Database and Analysis Resource (www.iedb.org). Applications will be evaluated for their scientific and technical merit, scientific and technical personnel, project management plan, and facilities and other resources available to accomplish the proposed studies.


It is anticipated that multiple cost reimbursement, completion type contracts will be awarded for a five-year period of performance beginning on or about September 1, 2014.


The NIAID estimates that the average annual total cost (direct and indirect costs combined) is $1.5 million per contract. However, it is anticipated that the total cost for the award(s) may vary depending upon the scope of the project and the technical objectives of the award(s). The length of time for which funding is requested should be consistent with the nature and complexity of the proposed research. In no event shall the period of performance proposed by an offeror exceed 5 years.


All responsible sources may submit a proposal which shall be considered by the Agency. This BAA will be available electronically on/about March 15, 2013, and may be accessed through FedBizOpps http://www.fedbizopps.gov/. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.

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Solicitation 1

Type:
Solicitation
Posted Date:
March 15, 2013
Description: BAA-NIAID-DAIT-NIHAI2013164 B Cell Epitope Discovery Mechanism of Antibody Protection

Amendment 1

Type:
Mod/Amendment
Posted Date:
March 15, 2013
Description: This Amendment is to revise the Attachment 1 - Packing and Delivery of the Proposal.

“For this solicitation, the NIAID requires proposals to be submitted in three methods: (1) Paper, (2) Disc (CD or DVD), and (3) Online via the NIAID electronic Contract Proposal Submission (eCPS) website. The content of the paper, disc, and online proposals must be identical. Submission of proposals by facsimile or e-mail is not acceptable.

For directions on using eCPS, go to the website https://ecps.niaid.nih.gov and then click on "How to Submit."

To submit online using eCPS, offerors must have a valid NIH electronic Research Administration (eRA) Commons account, which provides authentication and serves as a vehicle for secure transmission of documents and communication with the NIAID. The eRA Commons registration process may take up to 4 weeks. For more information, please see http://era.nih.gov/applicants/how-to_steps.cfm#register.”

Amendment 2

Type:
Mod/Amendment
Posted Date:
April 8, 2013
Description: Amendment 2 - Response to Questions.

Amendment 3

Type:
Mod/Amendment
Posted Date:
April 16, 2013
Description: Amendment 2 (2nd posting - questions 6 thru 8)
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Office of Acquisitions
6700 B Rockledge Room 3214 MSC7612
Bethesda, Maryland 20892-7612
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United States
:
MyLinh Pham,
Contract Specialist
Phone: 301-496-0993
Fax: 301-402-0972
:
Liem T. Nguyen,
Contracting Officer
Phone: 301-496-0612
Fax: 301-402-0972