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Training and Education Center (TEC) - Jackson Heart Study (JHS) Renewal

Solicitation Number: NHLBI-HV-13-11
Agency: Department of Health and Human Services
Office: National Institutes of Health
Location: National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD
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NHLBI-HV-13-11
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Combined Synopsis/Solicitation
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Added: Jun 13, 2012 3:10 pm
The Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), plans to establish at least one (1) Training and Education Center as part of the Jackson Heart Study (JHS) renewal. The JHS also involves a Coordinating Center, Field Center, and Community Outreach Center. Awards for the JHS are anticipated to be made on or about June 1, 2013.

The JHS is a multi-center investigation of predictors of cardiovascular disease (CVD) in 5,301 African-Americans living in Hinds, Madison, and Rankin Counties surrounding the Jackson, MS metropolitan area. The JHS represents an expansion of the Jackson, Mississippi site of the Atherosclerosis Risk in Communities (ARIC) Study to increase data collection in an African American population, and improve access to and the participation of African American populations and scientists in biomedical research and professions. The JHS was initiated in 1998 as a collaborative effort among three Jackson-area academic institutions. At the close of the current contracts in May 2013, the JHS will have completed three back-to-back cohort examinations that have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors and biochemical analytes; measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), computed tomography (CT) scans of the heart, aorta and abdomen; and stored biological samples. Eighty-two percent of the surviving JHS participants (N = 4,203) completed Exam 2; projected retention for Exam 3 is 80% (N = 4,082). In addition, the JHS has conducted annual cohort follow-up contacts for incident clinical events of interest, a variety of community education and outreach activities to promote healthy lifestyles to reduce disease risk burden, and level-appropriate academic training programs to promote and support public health research.


The objectives of the renewal of the JHS program are to:

1) Support dedicated time for JHS investigators to conduct data analysis and prepare manuscripts using the wealth of data collected.

2) Facilitate access to study resources and expertise in order to:
• Engage researchers beyond the JHS, including early career investigators, in collaborative analysis of existing data to produce high quality publications.
• Serve as a training ground for undergraduate and graduate students to help ameliorate the shortage of minority biomedical researchers.
• Serve as a platform for ancillary studies.

3) Conduct annual phone interviews with participants to identify interim hospitalizations and outpatient medical visits, convey information about the JHS, and serve as a vehicle to recruit for ancillary studies.

4) Continue clinical events identification, investigation, and validation to improve statistical power for risk prediction and hypothesis testing.

5) Perform community health education activities to disseminate health promotion and prevention messages in the Jackson community.


NHLBI plans to support one (1) Coordinating Center, one (1) Field Center, up to two (2) Training and Education Centers, and one (1) Community Outreach Center. THIS NOTICE ADDRESSES THE TRAINING AND EDUCATION CENTER ONLY. The Training and Education Center shall work collaboratively with the other study centers, including the Coordinating Center, Field Center, and Community Outreach Center, subcontractors, consultants, and the NHLBI Project Office in all relevant aspects of study development and execution. Training and Education Center shall maintain a database of all training activities; develop and implement evaluation metrics to evaluate effectiveness of the program annually. Training and Education Center shall participate actively in data analysis, presentation, and publications of important findings related to JHS study objectives, and prepare at least two manuscripts each year for submission for publication to peer-reviewed scientific journals. In addition, the TEC will conduct either or both:

a. A multi-year training and education enrichment program at the undergraduate level that integrates, builds upon, or complements existing undergraduate curricula for natural and behavioral science majors. The program shall include instruction in public health, chronic disease epidemiology, research methods, and other relevant topics; as well as integrated hands-on field training, observation of, or practicum in the conduct of the JHS appropriate to student academic level. The program must also provide internships or other opportunities for mentored independent study or research. The program shall accommodate up to 12 students per year at each academic level.

b. A multi-year training and education enrichment program at the graduate
level that integrates, builds upon, or complements an existing graduate program in or related to public health. The program shall include instruction in chronic disease epidemiology (including cardiovascular disease epidemiology), genetic epidemiology, research methods, bioethics, and biostatistics; as well as hands-on field training or practicum in the conduct of the JHS appropriate to the student academic level, and training in the Responsible Conduct of Research and Human Subjects Research. The program must also provide opportunities for independent study or research, including participation in a JHS research topical working group for data analysis and manuscript preparation. The program shall accommodate up to 10 students per year at each academic level.


Potential offerors are responsible for accessing this web site and downloading the RFP and any attachments. It is also the offerors' responsibility to monitor the FedBizOpps web page for the release of any amendments to the RFP. Interested parties must respond to the solicitation in order to be considered for award of any resultant contract. Letters of intent are due no later than July 13, 2012. This acquisition has been designated as a full and open competition under the North American Industry Classification System (NAICS) code 541712. Subcontracting opportunities are anticipated during the course of this contract award. Potential offerors are required to direct all questions via e-mail to william.etti@nih.gov.

NOTE: PREPARATION COSTS - This solicitation notice does not commit the Government to pay for preparation and submission of any materials.

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Solicitation with Statement of Work (SOW)

Type:
Other (Draft RFPs/RFIs, Responses to Questions, etc..)
Label:
Solicitation with Statement of Work (SOW)
Posted Date:
June 13, 2012
Description: Solicitation with Statement of Work (SOW)

Amendment 1

Type:
Mod/Amendment
Posted Date:
July 18, 2012
Description: Please see Amendment 1, which is a PDF attachment to this notice.

NHLBI-HV-13-11-Packaging-Delivery-of-Proposals

Type:
Other (Draft RFPs/RFIs, Responses to Questions, etc..)
Label:
NHLBI-HV-13-11-Packaging-Delivery-of-Proposals
Posted Date:
August 28, 2012
Description: Attachment 1, Packaging and Delivery of Propsals (R&D), to "NHLBI-HV-13-11-Solicitation-with-SOW" is inaccessible. The attachment is hereby provided as a separate file.

Amendment 2

Type:
Mod/Amendment
Posted Date:
September 7, 2012
Description: Amendment 2
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